{Reference Type}: Journal Article
{Title}: Optimization of Endoscopic Ultrasound Characteristics in the Diagnosis of Malignant Intraductal Papillary Mucinous Neoplasm.
{Author}: Kobayashi M;Niimi M;Katsuda H;Akahoshi K;Kinowaki Y;Sasaki M;Hirakawa A;Tateishi U;Tanabe M;Okamoto R;
{Journal}: Pancreas
{Volume}: 53
{Issue}: 6
{Year}: 2024 Jul 1
{Factor}: 3.243
{DOI}: 10.1097/MPA.0000000000002329
{Abstract}: <B>OBJECTIVE: </B>Endoscopic ultrasound (EUS) is an excellent diagnostic tool that provides high-resolution images of pancreatic cystic lesions. However, its role in the diagnosis of malignant intraductal papillary mucinous neoplasm (IPMN) remains limited and unclear. We aimed to determine the usefulness of this modality for such diagnosis.<BR><B>METHODS: </B>Overall, 246 patients who underwent EUS for IPMN after computed tomography (CT)/magnetic resonance imaging (MRI) from April 2018 to June 2021 were followed up until March 2022. We assessed the added value of performing EUS after CT or MRI for diagnosing malignant IPMN, using receiver operating characteristic curve analysis. Walls as thick as 2 mm were considered thickened in this study if they were highly uneven.<BR><B>RESULTS: </B>EUS clearly enhanced accuracy in identifying enhancing nodules and thickened walls. The areas under the receiver operating characteristic curve and corresponding 95% confidence intervals were 0.655 (0.549-0.760) and 0.566 (0.478-0.654) upon CT/MRI but 0.853 (0.763-0.942) and 0.725 (0.634-0.817) when observed using EUS. The combination of nodule size, thickened wall, and main duct size yielded the highest area under the receiver operating characteristic curve (0.944 [0.915-0.973]).<BR><B>CONCLUSIONS: </B>EUS more accurately detects malignant IPMN, as uneven wall thickening and certain nodules cannot be identified with CT/MRI.