{Reference Type}: Journal Article
{Title}: Tuneable thiol exchange linkers for traceless drug release applications in prodrugs and ADCs.
{Author}: Walther R;Park M;Ashman N;Welch M;Carroll JS;Spring DR;
{Journal}: Chem Commun (Camb)
{Volume}: 60
{Issue}: 55
{Year}: 2024 Jul 4
{Factor}: 6.065
{DOI}: 10.1039/d4cc01558d
{Abstract}: We describe a versatile and tuneable thiol responsive linker system using thiovinylketones, which relies on the conjugate addition-elimination mechanism of Michael acceptors for the traceless release of therapeutics. In a proof-of-principle study, we translate our findings to exhibit potent thiol-cleavable antibiotic prodrugs and antibody-drug conjugates.