{Reference Type}: Case Reports {Title}: Infectious Mononucleosis Revealed by Non-steroidal Anti-inflammatory Drug: A First Clinical Report. {Author}: Ahmed AI;Alkorbi HA;Jolo L;Al Kurbi M;Abbarh S;Danjuma M; {Journal}: Cureus {Volume}: 16 {Issue}: 5 {Year}: 2024 May 暂无{DOI}: 10.7759/cureus.60329 {Abstract}: Infectious mononucleosis (IM), primarily caused by the Epstein-Barr virus (EBV), is a common viral illness among adolescents and young adults. IM typically presents with symptoms such as fever, lymphadenopathy, and pharyngitis. We present a case of a 32-year-old woman who developed a maculopapular rash following ibuprofen administration, revealing an underlying undiagnosed IM. Laboratory investigations confirmed EBV infection. This represents the first documented case linking non-steroidal anti-inflammatory drugs (NSAIDs) to IM presentation. Awareness of this association is crucial for timely diagnosis and management, especially when evaluating patients with unexplained skin reactions to medications.