{Reference Type}: Journal Article
{Title}: Mortality prediction model from combined serial lactate, procalcitonin and calprotectin levels in critically ill patients with sepsis: A retrospective study according to Sepsis-3 definition.
{Author}: García de Guadiana-Romualdo L;Botella LA;Rodríguez Rojas C;Puche Candel A;Jimenez Sánchez R;Conesa Zamora P;Albaladejo-Otón MD;Allegue-Gallego JM;
{Journal}: Med Intensiva (Engl Ed)
{Volume}: 0
{Issue}: 0
{Year}: 2024 Jun 15
暂无{DOI}: 10.1016/j.medine.2024.05.015
{Abstract}: <B>OBJECTIVE: </B>1) To evaluate the ability of baseline and on 24 h serum calprotectin, in comparison to canonical biomarkers (lactate and procalcitonin), for prognosis of 28-day mortality in critically ill septic patients; and 2) To develop a predictive model combining the three biomarkers.<BR><B>METHODS: </B>A single-center, retrospective study.<BR><B>METHODS: </B>Intensive Care Unit of a university hospital.<BR><B>METHODS: </B>One hundred and seventy three septic pacientes were included.<BR><B>METHODS: </B>Measurement of baseline lactate, procalcitonin and calprotectin level and procalcitonin and calprotectin levels on 24 h.<BR><B>METHODS: </B>Demographics and comorbidities, SOFA score on ICU admission, baseline lactate, procalcitonin and calprotectin on admission and on 24 h and 28-day mortality.<BR><B>RESULTS: </B>1) On ICU admission, lactate was the only biomarker achieving a significant accuracy (AUC: 0.698); 2) On 24 h, no differences were found on procalcitonin and calprotectin levels. Procalcitonin and calprotectin clearances were significantly lower in non-survivors and both achieved a moderate performance (AUCs: 0.668 and 0.664, respectively); 3) A biomarker based-model achieved a significant accuracy (AUC: 0.766), trending to increase (AUC: 0.829) to SOFA score alone; y 4) Baseline lactate levels and procalcitonin and calprotectin clearance were independent predictors for the outcome.<BR><B>CONCLUSIONS: </B>1) Baseline and on 24 h calprotectina and procalcitonin levels lacked ability in predicting 28-day mortality; 2) Accuracy of clearance of both biomarkers was moderate; and 3) Combination of SOFA score and the predictive biomarker based-model showed a high prognostic accuracy.