{Reference Type}: Journal Article
{Title}: Cigarette smoking-related OLC1 overexpression associated with poor prognosis in bladder urothelial carcinoma.
{Author}: Chen H;Cai Z;Dong X;Chen W;Cao C;Zheng S;Wu J;Zhong D;Cheng S;Gao Y;Shou J;
{Journal}: Life Sci
{Volume}: 351
{Issue}: 0
{Year}: 2024 Aug 15
{Factor}: 6.78
{DOI}: 10.1016/j.lfs.2024.122821
{Abstract}: <B>OBJECTIVE: </B>To explore the clinical significance of OLC1 and cigarette smoking in bladder urothelial carcinoma (UBC).<BR><B>METHODS: </B>OLC1 mRNA expression was detected in 106 UBC samples by mRNA array or reverse real-time PCR. OLC1 protein expression in 114 UBC samples was detected by immunohistochemical staining. Wild-type C57BL/6J mice were injected with cigarette smoke condensate (n = 12) or exposed to cigarette smoke (n = 6) to investigate the correlations between cigarette smoking and OLC1 expression using mRNA array.<BR><B>RESULTS: </B>The mRNA and protein expression of OLC1 were higher in tumor samples (p < 0.01) and significantly correlated with tumor stage (p < 0.05). OLC1 protein expression and smoking history were correlated with disease-free survival (p < 0.05). OLC1 expression was significantly elevated in smoking patients with higher smoking intensity on both mRNA and protein levels (p < 0.05). Cigarette smoke exposure experiments revealed that OLC1 mRNA overexpressed in bladder uroepithelium of mice.<BR><B>CONCLUSIONS: </B>OLC1 could serve as a potential prognosis biomarker of UBC, especially for smoking patients.