{Reference Type}: Journal Article
{Title}: Fetal bradycardia in open versus fetoscopic prenatal repair of spina bifida.
{Author}: Papastefan ST;Alhajjat AM;Ott KC;Liesman DR;Langereis MM;Boat AC;Pombar XF;Kominiarek MA;Bowman RM;Shaaban AF;
{Journal}: Prenat Diagn
{Volume}: 44
{Issue}: 9
{Year}: 2024 08 14
{Factor}: 3.242
{DOI}: 10.1002/pd.6626
{Abstract}: To compare the occurrence of fetal bradycardia in open versus fetoscopic fetal spina bifida surgery.<BR>This is a single-institution retrospective cohort study of patients undergoing open (n = 25) or fetoscopic (n = 26) spina bifida repair between 2017 and 2022. From October 2017 to June 2020, spina bifida repairs were performed via an open classical hysterotomy, and from November 2020 to June 2022 fetoscopic repairs were performed following transition to this technique. Fetal heart rate (FHR) in beats per minute (bpm) was recorded via echocardiography every 15 min during the procedure. Cohort characteristics, fetal bradycardia and maternal physiologic parameters were compared between the groups.<BR>Fetuses undergoing an open repair more frequently developed bradycardia defined as <110 bpm (32% vs. 3.8%, p = 0.008), and a trend was observed for FHR decreases more than 25 bpm from baseline (20% vs. 3.8%, p = 0.073). Profound bradycardia less than 80 bpm was rare, occurring in only three operations (two in open, one in fetoscopic repair) with two fetuses (one in each group) requiring emergency cesarean delivery.<BR>When compared to open fetal surgery, fetal bradycardia occurred less frequently in fetoscopic surgery despite a significantly greater anesthetic exposure and the use of the intraamniotic carbon dioxide insufflation.