{Reference Type}: Journal Article
{Title}: Dorsal raphe nucleus to basolateral amygdala 5-HTergic neural circuit modulates restoration of consciousness during sevoflurane anesthesia.
{Author}: Yu Q;Wang Y;Gu L;Shao W;Gu J;Liu L;Lian X;Xu Q;Zhang Y;Yang Y;Zhang Z;Wu Y;Ma H;Shen Y;Ye W;Wu Y;Yang H;Chen L;Nagayasu K;Zhang H;
{Journal}: Biomed Pharmacother
{Volume}: 176
{Issue}: 0
{Year}: 2024 Jul 11
{Factor}: 7.419
{DOI}: 10.1016/j.biopha.2024.116937
{Abstract}: The advent of general anesthesia (GA) has significant implications for clinical practice. However, the exact mechanisms underlying GA-induced transitions in consciousness remain elusive. Given some similarities between GA and sleep, the sleep-arousal neural nuclei and circuits involved in sleep-arousal, including the 5-HTergic system, could be implicated in GA. Herein, we utilized pharmacology, optogenetics, chemogenetics, fiber photometry, and retrograde tracing to demonstrate that both endogenous and exogenous activation of the 5-HTergic neural circuit between the dorsal raphe nucleus (DR) and basolateral amygdala (BLA) promotes arousal and facilitates recovery of consciousness from sevoflurane anesthesia. Notably, the 5-HT1A receptor within this pathway holds a pivotal role. Our findings will be conducive to substantially expanding our comprehension of the neural circuit mechanisms underlying sevoflurane anesthesia and provide a potential target for modulating consciousness, ultimately leading to a reduction in anesthetic dose requirements and side effects.