{Reference Type}: Journal Article
{Title}: Clinical significance and normal reference value of serum creatinine to cystatin C ratio in children.
{Author}: Ota H;Fujimura T;Kunikata A;Yamagata T;Nozawa H;Ebishima H;Matsui H;
{Journal}: Clin Nutr ESPEN
{Volume}: 62
{Issue}: 0
{Year}: 2024 Aug 29
暂无{DOI}: 10.1016/j.clnesp.2024.05.021
{Abstract}: <B>OBJECTIVE: </B>Sarcopenia is a serious problem in adults and children. However, limited modalities are available for diagnosing pediatric sarcopenia. The serum creatinine to cystatin C ratio (Cre/CysC ratio) is a promising method for muscle quantification, although its clinical significance in the pediatric population is unknown. This study aimed to evaluate the relationship between the Cre/CysC ratio and physical performance.<BR><B>METHODS: </B>This was a single-center retrospective study. Patients aged <15 years who had visited the University of Tokyo Hospital for measurements of serum creatinine and cystatin C levels, body height, and body weight were included. The patients were assigned according to their age (<2 or ≥2 years), and the relationship between the Cre/CysC ratio and physical performance at the time of measurement was analyzed.<BR><B>RESULTS: </B>We included 266 patients, revealing a significant relationship between Cre/CysC ratio and physical performance in children aged ≥2 years (p < 0.001) but not in children aged <2 years (p = 0.42). The repeater-operator curve analysis of Cre/CysC to predict bedridden status showed good performance (the area under the curve was 0.82 (95% CI, 0.75-0.89)) and the cut-off value 0.44 had good accuracy (sensitivity 0.87, specificity 0.61).<BR><B>CONCLUSIONS: </B>The Cre/CysC ratio was a significant marker of impaired physical performance, and a Cre/CysC ratio <0.44 accurately predicted bedridden status in children aged >2 years.