{Reference Type}: Journal Article
{Title}: Ficini Reaction with Acrylates for the Stereoselective Synthesis of Aminocyclobutanes.
{Author}: Robert EGL;Waser J;
{Journal}: Chemistry
{Volume}: 0
{Issue}: 0
{Year}: 2024 Jun 13
{Factor}: 5.02
{DOI}: 10.1002/chem.202401810
{Abstract}: The first Ficini reaction between ynamides and acrylates is reported herein. The reaction is catalyzed by B(C6F5)3 acting as a Lewis acid and is giving access to stable tri-substituted aminocyclobutenes in high yield. The resulting products can be hydrogenated and epimerized under basic conditions or in presence of a Lewis acid, providing two distinct trans- aminocyclobutane monoester stereoisomers in high yield and diastereoisomeric ratio (up to quantitative yield and >99:1 dr).