{Reference Type}: Journal Article
{Title}: Immune stimulus exposure as a trigger for the development of chronic pruritus and circulating blood type 2 inflammation.
{Author}: Manjunath J;Liao V;Kambala A;Bao A;Kollhoff AL;Ma EZ;Imo BU;Cornman H;Reddy SV;Lee KK;Lu W;Yossef SM;Kwatra MM;Kwatra SG;
{Journal}: JAAD Int
{Volume}: 16
{Issue}: 0
{Year}: 2024 Sep
暂无{DOI}: 10.1016/j.jdin.2024.03.022
{Abstract}: <B>UNASSIGNED: </B>Chronic pruritus (CP) is a poorly characterized condition associated with intense pruritus without a primary skin eruption. This condition tends to emerge more commonly in older adults, and there is limited research on triggering factors.<BR><B>UNASSIGNED: </B>To explore the clinical characteristics and pathophysiology of CP following exposure to an immune stimulus.<BR><B>UNASSIGNED: </B>Clinical characteristics and plasma samples were collected from 15 patients who developed CP following an immune stimulus such as checkpoint inhibitors or vaccination. A multiplex panel was used to analyze plasma cytokine concentrations within these patients.<BR><B>UNASSIGNED: </B>Most immunotherapy-treated patients experienced CP during treatment or after 21 to 60 days of receiving treatment, while vaccine-stimulated patients developed pruritus within a week of vaccination. Plasma cytokine analysis revealed elevated levels of 12 cytokines in patients with immune-stimulated CP compared to healthy controls. Notably, T helper 2 (Th2) related cytokines interleukin (IL)-5 (fold change 2.65; q < 0.25) and thymic stromal lymphopoietin (fold change 1.61 q < 0.25) were upregulated.<BR><B>UNASSIGNED: </B>Limitations of this study include limited sample size, particularly in the plasma cytokine assay.<BR><B>UNASSIGNED: </B>This study reveals triggers of CP development and describes alterations in blood Th2 markers in patients with CP, including IgE, increased blood eosinophils, and cytokines IL-5 and thymic stromal lymphopoietin.