{Reference Type}: Journal Article
{Title}: The Influence of Pubertal Development on Autoantibody Appearance and Progression to Type 1 Diabetes in the TEDDY Study.
{Author}: Warncke K;Tamura R;Schatz DA;Veijola R;Steck AK;Akolkar B;Hagopian W;Krischer JP;Lernmark Å;Rewers MJ;Toppari J;McIndoe R;Ziegler AG;Vehik K;Haller MJ;Elding Larsson H;
{Journal}: J Endocr Soc
{Volume}: 8
{Issue}: 7
{Year}: 2024 May 23
暂无{DOI}: 10.1210/jendso/bvae103
{Abstract}: UNASSIGNED: The 2 peaks of type 1 diabetes incidence occur during early childhood and puberty.
UNASSIGNED: We sought to better understand the relationship between puberty, islet autoimmunity, and type 1 diabetes.
UNASSIGNED: The relationships between puberty, islet autoimmunity, and progression to type 1 diabetes were investigated prospectively in children followed in The Environmental Determinants of Diabetes in the Young (TEDDY) study. Onset of puberty was determined by subject self-assessment of Tanner stages. Associations between speed of pubertal progression, pubertal growth, weight gain, homeostasis model assessment of insulin resistance (HOMA-IR), islet autoimmunity, and progression to type 1 diabetes were assessed. The influence of individual factors was analyzed using Cox proportional hazard ratios.
UNASSIGNED: Out of 5677 children who were still in the study at age 8 years, 95% reported at least 1 Tanner Stage score and were included in the study. Children at puberty (Tanner Stage ≥2) had a lower risk (HR 0.65, 95% CI 0.45-0.93; P = .019) for incident autoimmunity than prepubertal children (Tanner Stage 1). An increase of body mass index Z-score was associated with a higher risk (HR 2.88, 95% CI 1.61-5.15; P < .001) of incident insulin autoantibodies. In children with multiple autoantibodies, neither HOMA-IR nor rate of progression to Tanner Stage 4 were associated with progression to type 1 diabetes.
UNASSIGNED: Rapid weight gain during puberty is associated with development of islet autoimmunity. Puberty itself had no significant influence on the appearance of autoantibodies or type 1 diabetes. Further studies are needed to better understand the underlying mechanisms.