{Reference Type}: Journal Article
{Title}: Beyond the danger signal: RNA aggregates orchestrate immunotherapy.
{Author}: Shubhra QTH;Feczkó T;Cai Q;
{Journal}: Trends Mol Med
{Volume}: 30
{Issue}: 8
{Year}: 2024 Aug 11
{Factor}: 15.272
{DOI}: 10.1016/j.molmed.2024.05.018
{Abstract}: Mendez-Gomez et al. recently demonstrated the transformative potential of RNA-lipid particle aggregates (RNA-LPAs) in immunotherapy. By reprogramming the tumor microenvironment (TME) and potentiating antitumor immunity, RNA-LPAs target primary tumors and elicit robust systemic immunity. This innovative platform holds promise for translating preclinical success into tangible clinical benefits.