{Reference Type}: Journal Article {Title}: Transforming Health Care from Volume to Value: Targeting Essential Therapies for Improved Health. {Author}: Tsourounis C;Chatterjee A;Pherson EC;Auron M; {Journal}: Am J Med {Volume}: 0 {Issue}: 0 {Year}: 2024 Jun 10 {Factor}: 5.928 {DOI}: 10.1016/j.amjmed.2024.06.004 {Abstract}: The healthcare landscape is evolving rapidly due to escalating costs from the traditional fee-for-service model. Value-based care has emerged as a viable solution, and initiatives focus on areas prone to overuse, waste, or high costs, such as advanced imaging and avoidable acute care resource utilization. Improving medication use is an important component of this work, and it requires organizational commitment, interdisciplinary collaboration, and targeted strategies for specific therapeutic areas. This review article discusses the value-based care approach to optimizing medications and blood product prescribing, spotlighting opportunities to reduce the overuse of opioid, antimicrobial, and proton pump inhibitor medications, alongside the underuse of guideline-based medical therapies in managing chronic diseases like coronary artery disease, heart failure, and chronic obstructive pulmonary disease.