{Reference Type}: Journal Article
{Title}: Ongoing pregnancy rates in single euploid frozen embryo transfers remain unaffected by female age: a retrospective study.
{Author}: Lawrenz B;Kalafat E;Ata B;Gallego RD;Melado L;Bayram A;Elkhatib I;Fatemi H;
{Journal}: Reprod Biomed Online
{Volume}: 49
{Issue}: 2
{Year}: 2024 Aug 19
{Factor}: 4.567
{DOI}: 10.1016/j.rbmo.2024.104074
{Abstract}: <B>OBJECTIVE: </B>Is female age a significant factor in the likelihood of an ongoing pregnancy in single euploid frozen embryo transfers (FET)?<BR><B>METHODS: </B>Retrospective study of 1923 single euploid FET cycles in 1464 women, either in a natural cycle or a hormone replacement therapy cycle. The primary outcome was the ongoing pregnancy rate (OPR).<BR><B>RESULTS: </B>There were 990 (51.48%) ongoing pregnancies among 1923 included transfers. The OPR were 51.4%, 49.1%, 53.3% and 52.3% for women aged ≤35, >35-≤37, >37-≤40 and >40 years at oocyte retrieval (OCR), without a significant trend for decreasing OPR (P = 0.679). No significant differences in female age at embryo transfer (P = 0.609) and female age at OCR (P = 0.816) were found between the groups (ongoing pregnancy versus no pregnancy or miscarriage). Women who received good-quality embryos (P < 0.001), had a lower body mass index (BMI) (P < 0.001), had achieved at least one pregnancy previously (P < 0.001), and underwent natural cycle endometrial preparation (P < 0.001) were more likely to achieve an ongoing pregnancy. Multivariable regression analysis (adjusted for BMI, embryo quality and endometrial preparation) did not show a significant effect of female age at OCR on achieving an ongoing pregnancy. Compared with women aged ≤35 years, none of the age groups had significantly higher or lower OPR. A multinomial regression analysis showed that BMI, embryo quality and endometrial preparation were associated with miscarriage/no pregnancy versus ongoing pregnancy (P = 0.001, 0.001 and 0.001, respectively). Female age had no significant association with either outcome.<BR><B>CONCLUSIONS: </B>Female age in itself does not have a substantial impact on the OPR in single euploid FET cycles, but the OPR is impacted significantly by embryo quality, BMI, previous parity, and a natural cycle endometrial preparation protocol.