{Reference Type}: Journal Article
{Title}: Biological Properties of Mentha viridis L. Essential Oil and Its Main Monoterpene Constituents.
{Author}: Omari NE;Chamkhi I;Bakrim S;Aanniz T;Benali T;Akhazzane M;Ullah R;Alotaibi A;Bari A;Elhrech H;Zengin G;Bouyahya A;
{Journal}: Chem Biodivers
{Volume}: 0
{Issue}: 0
{Year}: 2024 Jun 12
{Factor}: 2.745
{DOI}: 10.1002/cbdv.202401209
{Abstract}: This research aimed to evaluate the antidiabetic, dermatoprotective, and antibacterial activities of Mentha viridis L. essential oil (MVEO) collected in the province of Ouezzane (Northwest Morocco). Gas chromatography-mass spectrometry (GC-MS) analysis revealed that the main constituents of MVEO were carvone (37.26 %), 1,8-cineole (11.82 %), limonene (5.27 %), α-terpineol (4.16 %), and β-caryophyllene (4.04 %). MVEO showed strong inhibitory effects on α-amylase and α-glucosidase activities, exceeding those of acarbose, but weak anti-elastase activity. The main compounds, β-caryophyllene (IC50=79.91±2.24 and 62.08±2.78 μg/mL) and limonene (IC50=90.73±3.47 and 68.98±1, 60 μg/mL), demonstrated the strongest inhibitory effects on both digestive enzymes (α-glucosidase and α-amylase, respectively). In silico investigations, using molecular docking, also showed the inhibitory potential of these bioactive compounds against the enzymes tested. In conclusion, MVEO, due to its main components such as limonene, 1,8-cineole, β-caryophyllene, carvone, and α-terpineol, shows promising prospects for drug discovery and natural therapeutic applications.