{Reference Type}: Journal Article
{Title}: Outcomes of non-angiosarcoma radiation-associated soft tissue sarcomas of the chest.
{Author}: Garayua-Cruz L;Broida SE;Okuno SH;Robinson SI;Siontis BL;Welliver MX;Wilke BK;Goulding KA;Rose PS;Houdek MT;
{Journal}: J Surg Oncol
{Volume}: 130
{Issue}: 1
{Year}: 2024 Jul 12
{Factor}: 2.885
{DOI}: 10.1002/jso.27686
{Abstract}: BACKGROUND: Radiation-associated soft tissue sarcomas (RA-STS) are rare complications of patients receiving radiation therapy (RT) and are generally associated with a poor prognosis. Most of the literature surrounding RA-STS of the chest is centered on angiosarcoma. Therefore, we aim to document the management and outcome of patients with non-angiosarcoma RA-STS of the chest.
METHODS: We reviewed 17 patients (all female, median age 65 years) diagnosed with RA-STS. The most common primary malignancy was breast carcinoma (n = 15), with a median RT dose of 57.9 Gy. All patients underwent surgical resection; five patients (29%) received radiotherapy; and five patients (29%) received peri-operative chemotherapy.
RESULTS: The 5-year local recurrence and metastatic-free survival were 61% and 60%, while the 5-year disease-specific survival was 53%. Local recurrence was associated with death due to disease (HR 9.06, p = 0.01). Complications occurred in nine of patients, most commonly due to a wound complication (n = 7). At the most recent follow-up, the median Musculoskeletal Tumor Society Score was 63%.
CONCLUSIONS: RA-STS involving the chest wall are aggressive tumors with a high risk of local relapse and death due to disease. Local recurrence was associated with death due to disease; as such, we recommend aggressive surgical management with evaluation for adjuvant therapies.