{Reference Type}: Journal Article
{Title}: Tumor necrosis factor-α polymorphism and risk of primary nephrotic syndrome: A case-control study and meta-analysis.
{Author}: Zhao R;Wang Y;Zhou Y;Fan W;Yin H;
{Journal}: Immun Inflamm Dis
{Volume}: 12
{Issue}: 6
{Year}: 2024 Jun
{Factor}: 2.493
{DOI}: 10.1002/iid3.1278
{Abstract}: <B>BACKGROUND: </B>The current study aims to explore the relationship between tumor necrosis factor-α (TNF-α) polymorphism and the risk of primary nephrotic syndrome (PNS).<BR><B>METHODS: </B>A total of 250 PNS patients were selected for this study, as well as 300 volunteers serving as the control group. TNF-α polymorphism were assessed using the polymerase chain reaction-restriction fragment length polymorphism method. In addition, a meta-analysis was conducted to analyze previously published literature on this topic.<BR><B>RESULTS: </B>No significant differences were observed in the genotypes frequency or alleles frequency among the study populations. Meta-analysis results revealed a positive association between TNF-α rs1800629 polymorphism and allele contrast in African populations (p = 0), homozygote comparison (p = .007), heterozygote comparison (p = .026), recessive genetic model (p = .011), and dominant genetic model (p = .000).<BR><B>CONCLUSIONS: </B>TNF-α rs1800629 polymorphism does not appear to confer any increased risk for PNS.