{Reference Type}: Journal Article
{Title}: Single-cell analysis of tumor microenvironment and cell adhesion reveals that interleukin-1 beta promotes cancer cell proliferation in breast cancer.
{Author}: Wang W;Dong G;Yang Z;Li S;Li J;Wang L;Zhu Q;Wang Y;
{Journal}: Animal Model Exp Med
{Volume}: 0
{Issue}: 0
{Year}: 2024 Jun 11
暂无{DOI}: 10.1002/ame2.12445
{Abstract}: <B>BACKGROUND: </B>Triple-negative breast cancer (TNBC), which is so called because of the lack of estrogen receptors (ER), progesterone receptors (PR), and human epidermal growth factor receptor 2 (HER2) receptors on the cancer cells, accounts for 10%-15% of all breast cancers. The heterogeneity of the tumor microenvironment is high. However, the role of plasma cells controlling the tumor migration progression in TNBC is still not fully understood.<BR><B>METHODS: </B>We analyzed single-cell RNA sequencing data from five HER2 positive, 12 ER positive/PR positive, and nine TNBC samples. The potential targets were validated by immunohistochemistry.<BR><B>RESULTS: </B>Plasma cells were enriched in TNBC samples, which was consistent with validation using data from The Cancer Genome Atlas. Cell communication analysis revealed that plasma cells interact with T cells through the intercellular adhesion molecule 2-integrin-aLb2 complex, and then release interleukin 1 beta (IL1B), as verified by immunohistochemistry, ultimately promoting tumor growth.<BR><B>CONCLUSIONS: </B>Our results revealed the role of plasma cells in TNBC and identified IL1B as a new prognostic marker for TNBC.