{Reference Type}: English Abstract
{Title}: [Clinical analysis of endonasal endoscopic surgery in esthesioneuroblastoma].
{Author}: Gu Y;Mao S;Tang R;Li Z;Zhang W;
{Journal}: Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
{Volume}: 38
{Issue}: 6
{Year}: 2024 Jun
暂无{DOI}: 10.13201/j.issn.2096-7993.2024.06.009
{Abstract}: Objective:To investigate the clinical characteristics of esthesioneuroblastoma and the efficacy of endonasal endoscopic surgery combined with radiotherapy/chemotherapy. Methods:The clinical and surgical data of 17 patients with esthesioneuroblastoma who underwent endonasal endoscopic surgery in our department from September 2009 to June 2023 were retrospectively analyzed. Results:Among all patients, the modified Kadish stage B was identified in 4 patients, C in 10 patients, and D in 3 patients. Ten of them underwent endonasal endoscopic surgery without neck dissection in one day, whose average operation time is （5.2±2.5） hours and average blood loss is （192±162）mL. Skull base reconstructions were performed in 15 patients, postoperative complications were observed in 3 patients, and negative margins were obtained in 13 patients. All 17 patients were followed up for an average of （49.7±40.2） months. Three patients died and 6 had recurrence and/or metastasis. The 1-year, 2-year and 5-year overall survival rates were 88.2%, 80.2%, and 80.2%, respectively, and the 1-year, 2-year and 5-year disease-free survival rates were 82.4%, 82.4%, and 50.8%, respectively. The 2-year overall survival rates of patients with negative and positive margins were 100% and 25%, respectively, while the 2-year disease-free survival rates were 61.5% and 25.0%, respectively. Conclusion:Endonasal endoscopic surgery combined with radiotherapy/chemotherapy can achieve satisfactory effect in esthesioneuroblastoma, and the prognosis of patients with positive margins is poor.<BR>目的：探讨嗅神经母细胞瘤的临床特点和经鼻内镜手术联合放/化疗的治疗效果。 方法：回顾性分析2009年9月—2023年6月我院收治的接受经鼻内镜手术治疗的17例嗅神经母细胞瘤患者的临床、手术资料及随访结果。 结果：17例患者中改良Kadish B期4例，C期10例，D期3例。10例患者一期行鼻内镜手术切除肿瘤（除外颈清），平均手术时长（5.2±2.5） h，平均出血量为（192.0±162.0） mL。15例患者行颅底重建，3例患者出现术后并发症，13例患者达到阴性切缘。所有患者均得以随访，平均随访（49.7±40.2）个月，死亡3例，复发和（或）转移6例。1、2和5年总体生存率分别为88.2%、80.2%和80.2%，1、2和5年无病生存率分别为82.4%、82.4%和50.8%。切缘阴性和切缘阳性的患者2年总体生存率分别为100.0%和25.0%，2年无病生存率分别为61.5%和25.0%。 结论：经鼻内镜手术联合放/化疗治疗嗅神经母细胞瘤疗效可靠，切缘阳性患者预后较差。.