{Reference Type}: Journal Article
{Title}: Highly Colistin-resistant Aeromonas jandaei from a Human Blood Sample.
{Author}: Komeda T;Shrestha S;Sherchan JB;Tohya M;Hishinuma T;Shrechand JB;Tada T;Kirikae T;
{Journal}: Juntendo Iji Zasshi
{Volume}: 69
{Issue}: 3
{Year}: 2023
暂无{DOI}: 10.14789/jmj.JMJ22-0047-R
{Abstract}: Aeromonas species are Gram-negative rods known to cause infections such as gastroenteritis, bacteremia and wound infections. Colistin is one of few treatments for multidrug-resistant Gram-negative bacteria. However, colistin-resistant bacteria carrying the mobilized colistin resistance (mcr) gene are a threat in healthcare settings worldwide. In recent years, colistin-resistant Aeromonas species have been detected in environmental and clinical samples. We analyzed the genomic characteristics of one highly colistin-resistant A. jandaei isolated from a blood sample in Nepal, which harbored four novel mcr-like genes on its chromosome. Our study strongly suggests that A. jandaei is a reservoir of colistin-resistant genes. Inappropriate use of drugs in medicine and food production should be reduced and continued global surveillance for colistin-resistant bacteria is necessary.