{Reference Type}: Journal Article {Title}: Three-dimensional finite element analysis of the optimal mechanical design for maximum inward movement of the anterior teeth with clear aligners. {Author}: Chen J;Zhu D;Zhao M;Cheng Z;Pan Y;Liu X; {Journal}: Sci Rep {Volume}: 14 {Issue}: 1 {Year}: 2024 06 8 {Factor}: 4.996 {DOI}: 10.1038/s41598-024-63907-x {Abstract}: This study aims to refine clinical designs within clear aligner therapy, exploring the appropriate ratio of anterior tooth retraction to intrusion under maximum anchorage. Using a three-dimensional finite element model and evaluating 19 load scenarios with first premolar extraction, the research identifies the optimal force angle for anterior tooth retraction as 45 to 55°. For clinical planning, it is recommended to design a retraction of 0.19 mm combined with an intrusion of 0.16 mm to achieve anterior tooth retraction. This investigation is crucial for enhancing understanding of biomechanical principles in clear aligner orthodontics, offering significant insights for effective treatments.