{Reference Type}: Journal Article {Title}: Evidence-based coaching of core competencies in epidemiology, using the framework of randomized controlled trials: the Zurich approach. {Author}: Radtke T;von Wyl V;Haile SR;Rohrmann S;Frei A;Puhan MA; {Journal}: Int J Epidemiol {Volume}: 53 {Issue}: 3 {Year}: 2024 Apr 11 {Factor}: 9.685 {DOI}: 10.1093/ije/dyae075 {Abstract}: Teaching epidemiological concepts in academic settings poses a challenge due to the intricate nature of the discipline as both a science and a practice. Whereas traditional classroom-based teaching methods are commonly employed, evidence suggests they may not be the most effective approach for fostering core competencies and skills required in real-life scientific work. In this article, we describe our process of transitioning from traditional classroom teaching of epidemiology towards practice-based coaching to convey epidemiological concepts to bachelor's and master's students in Biomedicine. We chose the framework of randomized controlled trials (RCT) since they offer a great opportunity to teach epidemiological concepts in a hands-on course. This practice-based course encompasses the entire life cycle of a study, allowing students to design and conduct a short-term experiment, analyse its data and prepare a scientific paper. We provide a comprehensive overview of the course structure, content, learning objectives and course evaluation, while also discussing the advantages and disadvantages of this innovative format. Our approach offers a promising alternative to classroom teaching by incorporating practical, hands-on experiences offering students a high level of independence and self-determination, as well as facilitation and coaching by faculty. It has the potential to be applied across diverse academic settings, providing students with valuable skills and competencies in epidemiology.