{Reference Type}: Journal Article
{Title}: Predictive value of sarcopenia components for all-cause mortality: findings from population-based cohorts.
{Author}: Westbury LD;Harvey NC;Beaudart C;Bruyère O;Cauley JA;Cawthon P;Cruz-Jentoft AJ;Curtis EM;Ensrud K;Fielding RA;Johansson H;Kanis JA;Karlsson MK;Lane NE;Lengelé L;Lorentzon M;McCloskey E;Mellström D;Newman AB;Ohlsson C;Orwoll E;Reginster JY;Ribom E;Rosengren BE;Schousboe JT;Dennison EM;Cooper C; ;
{Journal}: Aging Clin Exp Res
{Volume}: 36
{Issue}: 1
{Year}: 2024 Jun 6
{Factor}: 4.481
{DOI}: 10.1007/s40520-024-02783-x
{Abstract}: <B>BACKGROUND: </B>Low grip strength and gait speed are associated with mortality. However, investigation of the additional mortality risk explained by these measures, over and above other factors, is limited.<BR><B>OBJECTIVE: </B>We examined whether grip strength and gait speed improve discriminative capacity for mortality over and above more readily obtainable clinical risk factors.<BR><B>METHODS: </B>Participants from the Health, Aging and Body Composition Study, Osteoporotic Fractures in Men Study, and the Hertfordshire Cohort Study were analysed. Appendicular lean mass (ALM) was ascertained using DXA; muscle strength by grip dynamometry; and usual gait speed over 2.4-6 m. Verified deaths were recorded. Associations between sarcopenia components and mortality were examined using Cox regression with cohort as a random effect; discriminative capacity was assessed using Harrell's Concordance Index (C-index).<BR><B>RESULTS: </B>Mean (SD) age of participants (n = 8362) was 73.8(5.1) years; 5231(62.6%) died during a median follow-up time of 13.3 years. Grip strength (hazard ratio (95% CI) per SD decrease: 1.14 (1.10,1.19)) and gait speed (1.21 (1.17,1.26)), but not ALM index (1.01 (0.95,1.06)), were associated with mortality in mutually-adjusted models after accounting for age, sex, BMI, smoking status, alcohol consumption, physical activity, ethnicity, education, history of fractures and falls, femoral neck bone mineral density (BMD), self-rated health, cognitive function and number of comorbidities. However, a model containing only age and sex as exposures gave a C-index (95% CI) of 0.65(0.64,0.66), which only increased to 0.67(0.67,0.68) after inclusion of grip strength and gait speed.<BR><B>CONCLUSIONS: </B>Grip strength and gait speed may generate only modest adjunctive risk information for mortality compared with other more readily obtainable risk factors.