{Reference Type}: Journal Article
{Title}: FAP expression dynamics and role in silicosis: Insights from epidemiological and experimental models.
{Author}: Deng X;Cheng Z;Li Y;Duan M;Qi J;Hao C;Yao W;
{Journal}: Environ Pollut
{Volume}: 356
{Issue}: 0
{Year}: 2024 Sep 1
{Factor}: 9.988
{DOI}: 10.1016/j.envpol.2024.124311
{Abstract}: Prolonged exposure to free silica leads to the development of silicosis, wherein activated fibroblasts play a pivotal role in its pathogenesis and progression. Fibroblast Activation Protein (FAP), as a biomarker for activated fibroblasts, its expression pattern and role in key aspects of silicosis pathogenesis remain unclear. This study elucidated the expression pattern and function of FAP through population-based epidemiological investigations, establishment of mouse models of silicosis, and in vitro cellular models. Results indicated a significant elevation of FAP in plasma from silicosis patients and lung tissues from mouse models of silicosis. In the cellular model, we observed a sharp increase in FAP expression early in the differentiation process, which remained high expression. Inhibition of FAP suppressed fibroblast differentiation, while overexpression of FAP produced the opposite effect. Moreover, fibroblast-derived FAP can alter the phenotype and function of neighboring macrophages. In summary, we revealed a high expression pattern of FAP in silicosis and its potential mechanistic role in fibrosis, suggesting FAP as a potential therapeutic target for silicosis.