{Reference Type}: Journal Article
{Title}: Transient Bacillary Layer Detachment During the Disease Course of Primary Vitreoretinal Lymphoma.
{Author}: Casalino G;Malerba A;Fabris S;Bolli N;Croci GA;Pellegrini M;Rossi FG;Mapelli C;Viola F;
{Journal}: Ocul Immunol Inflamm
{Volume}: 0
{Issue}: 0
{Year}: 2024 Jun 5
{Factor}: 3.728
{DOI}: 10.1080/09273948.2024.2359627
{Abstract}: <B>UNASSIGNED: </B>To report the clinical course and the retinal imaging features of a case of cytology-proven primary vitreoretinal lymphoma (PVRL) presenting with a transient bacillary layer detachment (BALAD) during the disease course.<BR><B>UNASSIGNED: </B>Observational case report.<BR><B>UNASSIGNED: </B>A 50 year-old woman was referred to us with a 2-month history of vitritis in both eyes, poorly responding to oral prednisolone. After discontinuation of oral prednisolone, worsening of vitritis and the appearance of multiple creamy-like subretinal infiltrates in the mid-peripheral retina of both eyes, along with the exclusion of common causes of intermediate/posterior uveitis, made us consider PVRL. Aqueous humor sampling detected MYD88 L265P mutation, and subsequent diagnostic pars plana vitrectomy in the left eye yielded a positive cytology for large B cell lymphoma consistent with PVRL. During the disease course, optical coherence tomography of the macula showed a BALAD in the right eye, which resolved during follow-up.<BR><B>UNASSIGNED: </B>Our case indicates that BALAD is a possible rare manifestation of PVRL, and this should be considered in the differential diagnosis process in order to avoid diagnostic delays.