{Reference Type}: Journal Article
{Title}: The HERCulean task of recognizing, ubiquitinating, and shielding misfolded integral membrane proteins.
{Author}: Guerriero CJ;Brodsky JL;
{Journal}: J Cell Biol
{Volume}: 223
{Issue}: 7
{Year}: 2024 Jul 1
{Factor}: 8.077
{DOI}: 10.1083/jcb.202405160
{Abstract}: During ER-associated decay, unfolded membrane-resident proteins are targeted for removal and degradation by ubiquitin ligases whose identities and precise operations remain unclear. In this issue, Guerriero and Brodsky discuss new results from Kamada et al. (https://doi.org/10.1083/jcb.202308003) showing the clearance of misfolded CFTR by the E3 ligase HERC3.