{Reference Type}: Journal Article
{Title}: The economic rationale for cell-based influenza vaccines in children and adults: A review of cost-effectiveness analyses.
{Author}: Fisman D;Giglio N;Levin MJ;Nguyen VH;Pelton SI;Postma M;Ruiz-Aragón J;Urueña A;Mould-Quevedo JF;
{Journal}: Hum Vaccin Immunother
{Volume}: 20
{Issue}: 1
{Year}: 2024 Dec 31
{Factor}: 4.526
{DOI}: 10.1080/21645515.2024.2351675
{Abstract}: Seasonal influenza significantly affects both health and economic costs in children and adults. This narrative review summarizes published cost-effectiveness analyses (CEAs) of cell-based influenza vaccines in children and adults <65 years of age, critically assesses the assumptions and approaches used in these analyses, and considers the role of cell-based influenza vaccines for children and adults. CEAs from multiple countries demonstrated the cost-effectiveness of cell-based quadrivalent influenza vaccines (QIVc) compared with egg-based trivalent/quadrivalent influenza vaccines (TIVe/QIVe). CEA findings were consistent across models relying on different relative vaccine effectiveness (rVE) estimate inputs, with the rVE of QIVc versus QIVe ranging from 8.1% to 36.2% in favor of QIVc. Across multiple scenarios and types of analyses, QIVc was consistently cost-effective compared with QIVe, including in children and adults across different regions of the world.