{Reference Type}: Journal Article {Title}: Interplay between male gonadal function and overall male health. {Author}: Asero V;Scornajenghi CM;Iaconis S;Sicignano E;Falcone A;Dinacci F;Pagano G;Carino D;Corvino R;Tresh A; {Journal}: J Basic Clin Physiol Pharmacol {Volume}: 35 {Issue}: 3 {Year}: 2024 May 1 暂无{DOI}: 10.1515/jbcpp-2024-0054 {Abstract}: The process-of-male reproduction is intricate, and various medical conditions-have the potential to disrupt spermatogenesis. Moreover, infertility in males can serve as an indicator of-potential future health issue. Numerous conditions with systemic implications have been identified, encompassing genetic factors (such as Klinefelter Syndrome), obesity, psychological stress, environmental factors, and others. Consequently, infertility assessment-presents an opportunity for comprehensive health counseling, extending-beyond discussions about reproductive goals. Furthermore, male infertility has been suggested as a harbinger of future health problems, as poor semen quality and a diagnosis of-male infertility are associated with an increased risk of hypogonadism, cardiometabolic disorders, cancer, and even mortality. This review explores the existing-literature on the relationship between systemic illnesses and male fertility, impacting both clinical-outcomes and semen parameters. The majority of the literature analyzed, which compared gonadal function with genetic, chronic, infectious or tumoral diseases, confirm the association between overall male health and infertility.