{Reference Type}: Journal Article
{Title}: Viscosity-Induced Emission of 5-(Diarylmethylene)imidazolone with Extended Conjugation via Attachment of N-Methylpyrrole at the 2-Position.
{Author}: Ikejiri M;Yoshimizu A;Shiota F;Nagayama A;Fujisaka A;Kuboki Y;Miyashita K;
{Journal}: Chem Pharm Bull (Tokyo)
{Volume}: 72
{Issue}: 5
{Year}: 2024
{Factor}: 1.903
{DOI}: 10.1248/cpb.c24-00143
{Abstract}: We have developed a series of 2-monoaryl-5-diarylmethylene analogs of the green fluorescent protein chromophore to study their viscosity-induced emission (VIE) properties. The analogs were synthesized by a condensation with methyl imidate and N-(diarylmethylene)glycinate. Among the analogs, the N-methylpyrrol-2-yl-substituted analog 1h induced the most remarkable VIE behavior in triglyceride and lipid bilayers probably due to the high π-electron-rich property of the pyrrole ring. The pyrrole substituent in imidazolone analogs can be expected to become a common template for introducing VIE behavior.