{Reference Type}: Journal Article
{Title}: Structural and functional disruption of subcortical limbic structures related with executive function in pediatric bipolar disorder.
{Author}: Liu H;Gao W;Jiao Q;Cao W;Guo Y;Cui D;Shi Y;Sun F;Su L;Lu G;
{Journal}: J Psychiatr Res
{Volume}: 175
{Issue}: 0
{Year}: 2024 May 27
{Factor}: 5.25
{DOI}: 10.1016/j.jpsychires.2024.05.041
{Abstract}: <B>BACKGROUND: </B>Impaired cognition has been demonstrated in pediatric bipolar disorder (PBD). The subcortical limbic structures play a key role in PBD. However, alternations of anatomical and functional characteristics of subcortical limbic structures and their relationship with neurocognition of PBD remain unclear.<BR><B>METHODS: </B>Thirty-six PBD type I (PBD-I) (15.36 ± 0.32 years old), twenty PBD type II (PBD-II) (14.80 ± 0.32 years old) and nineteen age-gender matched healthy controls (HCs) (14.16 ± 0.36 years old) were enlisted. Primarily, the volumes of the subcortical limbic structures were obtained and differences in the volumes were evaluated. Then, these structures served as seeds of regions of interest to calculate the voxel-wised functional connectivity (FC). After that, correlation analysis was completed between volumes and FC of brain regions showing significant differences and neuropsychological tests.<BR><B>RESULTS: </B>Compared to HCs, both PBD-I and PBD-II patients showed a decrease in the Stroop color word test (SCWT) and digit span backward test scores. Compared with HCs, PBD-II patients exhibited a significantly increased volume of right septal nuclei, and PBD-I patients presented increased FC of right nucleus accumbens and bilateral pallidum, of right basal forebrain with right putamen and left pallidum. Both the significantly altered volumes and FC were negatively correlated with SCWT scores.<BR><B>CONCLUSIONS: </B>The study revealed the role of subcortical limbic structural and functional abnormalities on cognitive impairments in PBD patients. These may have far-reaching significance for the etiology of PBD and provide neuroimaging clues for the differential diagnosis of PBD subtypes.<BR><B>CONCLUSIONS: </B>Distinctive features of neural structure and function in PBD subtypes may contribute to better comprehending the potential mechanisms of PBD.