{Reference Type}: Journal Article
{Title}: Identification and treatment of surgically-remediable causes of infantile epileptic spasms syndrome.
{Author}: Macdonald-Laurs E;Dzau W;Warren AEL;Coleman M;Mignone C;Stephenson SEM;Howell KB;
{Journal}: Expert Rev Neurother
{Volume}: 24
{Issue}: 7
{Year}: 2024 Jul 30
{Factor}: 4.287
{DOI}: 10.1080/14737175.2024.2360117
{Abstract}: <B>UNASSIGNED: </B>Infantile epileptic spasms syndrome (IESS) is a common developmental and epileptic encephalopathy with poor long-term outcomes. A substantial proportion of patients with IESS have a potentially surgically remediable etiology. Despite this, epilepsy surgery is underutilized in this patient group. Some surgically remediable etiologies, such as focal cortical dysplasia and malformation of cortical development with oligodendroglial hyperplasia in epilepsy (MOGHE), are under-diagnosed in infants and young children. Even when a surgically remediable etiology is recognised, for example, tuberous sclerosis or focal encephalomalacia, epilepsy surgery may be delayed or not considered due to diffuse EEG changes, unclear surgical boundaries, or concerns about operating in this age group.<BR><B>UNASSIGNED: </B>In this review, the authors discuss the common surgically remediable etiologies of IESS, their clinical and EEG features, and the imaging techniques that can aid in their diagnosis. They then describe the surgical approaches used in this patient group, and the beneficial impact that early epilepsy surgery can have on developing brain networks.<BR><B>UNASSIGNED: </B>Epilepsy surgery remains underutilized even when a potentially surgically remediable cause is recognized. Overcoming the barriers that result in under-recognition of surgical candidates and underutilization of epilepsy surgery in IESS will improve long-term seizure and developmental outcomes.