{Reference Type}: Journal Article
{Title}: Ictal activity is sustained by the estrogen receptor β during the estrous cycle.
{Author}: Li FR;Lévesque M;Wang S;Carreño-Muñoz MI;Di Cristo G;Avoli M;
{Journal}: Curr Res Neurobiol
{Volume}: 6
{Issue}: 0
{Year}: 2024
暂无{DOI}: 10.1016/j.crneur.2024.100131
{Abstract}: Catamenial epilepsy, defined as a periodicity of seizure exacerbation during the menstrual cycle, affects up to 70 % of epileptic women. Seizures in these patients are often non-responsive to medication; however, our understanding of the relation between menstrual cycle and seizure generation (i.e. ictogenesis) remains limited. We employed here field potential recordings in the in vitro 4-aminopyridine model of epileptiform synchronization in female mice (P60-P130) and found that: (i) the estrous phase favors ictal activity in the entorhinal cortex; (ii) these ictal discharges display an onset pattern characterised by the presence of chirps that are thought to mirror synchronous interneuron firing; and (iii) blocking estrogen receptor β-mediated signaling reduces ictal discharge duration. Our findings indicate that the duration of 4AP-induced ictal discharges, in vitro, increases during the estrous phase, which corresponds to the human peri-ovulatory period. We propose that these effects are caused by the presumptive enhancement of interneuron excitability due to increased estrogen receptor β-mediated signaling.