{Reference Type}: Journal Article
{Title}: Donor genetic burden for cerebrovascular risk and kidney transplant outcome.
{Author}: Collins KE;Gilbert E;Mauduit V;Benson KA;Elhassan EAE;O'Seaghdha C;Hill C;McKnight AJ;Maxwell AP;van der Most PJ;de Borst MH;Guan W;Jacobson PA;Israni AK;Keating BJ;Lord GM;Markkinen S;Helanterä I;Hyvärinen K;Partanen J;Madden SF;Limou S;Cavalleri GL;Conlon PJ;
{Journal}: J Nephrol
{Volume}: 0
{Issue}: 0
{Year}: 2024 May 29
{Factor}: 4.393
{DOI}: 10.1007/s40620-024-01973-0
{Abstract}: <B>OBJECTIVE: </B>Kidney grafts from donors who died of stroke and related traits have worse outcomes relative to grafts from both living donors and those who died of other causes. We hypothesise that deceased donors, particularly those who died of stroke, have elevated polygenic burden for cerebrovascular traits. We further hypothesise that this donor polygenic burden is associated with inferior graft outcomes in the recipient.<BR><B>METHODS: </B>Using a dataset of 6666 deceased and living kidney donors from seven different European ancestry transplant cohorts, we investigated the role of polygenic burden for cerebrovascular traits (hypertension, stroke, and intracranial aneurysm (IA)) on donor age of death and recipient graft outcomes.<BR><B>RESULTS: </B>We found that kidney donors who died of stroke had elevated intracranial aneurysm and hypertension polygenic risk scores, compared to healthy controls and living donors. This burden was associated with age of death among donors who died of stroke. Increased donor polygenic risk for hypertension was associated with reduced long term graft survival (HR: 1.44, 95% CI [1.07, 1.93]) and increased burden for hypertension, and intracranial aneurysm was associated with reduced recipient estimated glomerular filtration rate (eGFR) at 1 year.<BR><B>CONCLUSIONS: </B>Collectively, the results presented here demonstrate the impact of inherited factors associated with donors' death on long-term graft function.