{Reference Type}: Case Reports
{Title}: Anti-PF4 ELISA-Negative, SRA-Positive Heparin-Induced Thrombocytopenia.
{Author}: Attah A;Peterson C;Jacobs M;Bhagavatula R;Shah D;Kaplan R;Samhouri Y;
{Journal}: Hematol Rep
{Volume}: 16
{Issue}: 2
{Year}: 2024 May 9
暂无{DOI}: 10.3390/hematolrep16020029
{Abstract}: Heparin products are frequently used in the inpatient setting to prevent and treat venous thromboembolism, but they simultaneously put patients at risk of developing heparin-induced thrombocytopenia (HIT). The 4Ts score determines the pretest probability of HIT. Diagnosis is made with a screening antiplatelet factor (PF4) immunoassay and the serotonin-release assay (SRA) as a confirmatory test. Anti-PF4 assays have high sensitivity (98%) but lower specificity (50%) and result in frequent false-positive tests. We present a rare case from our institution of a patient with anti-PF4-Polyanion ELISA-negative, SRA-positive HIT and describe the challenges in making a timely diagnosis in this case.