{Reference Type}: Journal Article
{Title}: Cerebellum/liver index on baseline 18F-FDG PET/CT to improve prognostication in post-transplant lymphoproliferative disorders: a multicenter retrospective study.
{Author}: Morland D;Kanagaratnam L;Hubelé F;Toussaint E;Choquet S;Kas A;Caquot PA;Haioun C;Itti E;Leprêtre S;Decazes P;Bijou F;Schwartz P;Jacquet C;Chauchet A;Matuszak J;Kamar N;Payoux P; ;Durot E;
{Journal}: EJNMMI Res
{Volume}: 14
{Issue}: 1
{Year}: 2024 May 27
{Factor}: 3.434
{DOI}: 10.1186/s13550-024-01111-8
{Abstract}: <B>BACKGROUND: </B>Besides International Prognostic Index (IPI) score, baseline prognostic factors of post-transplant lymphoproliferative disorders (PTLD) are poorly identified due to the rarity of the disease. New indexes derived from healthy organ uptake in baseline 18F-FDG PET/CT have been studied in immunocompetent lymphoma patients. The aim of this study is to evaluate the performances of the cerebellum-to-liver uptake ratio (denoted as CLIP) as a prognostic factor for PFS and OS. This retrospective multicenter study is based on patients with PTLD included in the K-VIROGREF cohort. The previously published threshold of 3.24 was used for CLIP in these analyses.<BR><B>RESULTS: </B>A total of 97 patients was included with a majority of monomorphic diffuse large B-cell lymphoma subtype (78.3%). Both IPI score (≥ 3) and CLIP (< 3.24) were significant risk factors of PFS with corresponding hazard ratios of 2.0 (1.0-4.0) and 2.4 (1.3-4.5) respectively. For OS, CLIP was not significant and resulted in a hazard ratio of 2.6 (p = 0.059). Neither IPI score or Total Metabolic Tumor Volume reached significance for OS.<BR><B>CONCLUSIONS: </B>CLIP is a promising predictor of PFS and perhaps OS in PTLD. Further prospective studies are needed to confirm these results.