{Reference Type}: Journal Article {Title}: Bridging the Evidence and Practice Gap in Chronic Kidney Disease: A System Thinking Approach to Population Health. {Author}: Padiyar A;Sarabu N;Ahlawat S;Thatcher EJ;Roeper BA;Anantharamakrishnan A;Runnels P;Bahner C;Lang SE;Barnett TD;Raghuwanshi Y;Pronovost PJ; {Journal}: Popul Health Manag {Volume}: 27 {Issue}: 3 {Year}: 2024 Jun 27 {Factor}: 2.29 {DOI}: 10.1089/pop.2023.0275 {Abstract}: Chronic kidney disease (CKD) is common, costly, and life-limiting, requiring dialysis and transplantation in advanced stages. Although effective guideline-based therapy exists, the asymptomatic nature of CKD together with low health literacy, adverse social determinants of health, unmet behavioral health needs, and primary care providers' (PCP) limited understanding of CKD result in defects in screening and diagnosis. Care is fragmented between PCPs and specialty nephrologists, with limited time, expertise, and resources to address systemic gaps. In this article, the authors define how they classified defects in care and report the current numbers of patients exposed to these defects, both nationally and in their health system Accountable Care Organization. They describe use of the health system's three-pillar leadership model (believing, belonging, and building) to empower providers to transform CKD care. Believing entailed engaging individuals to believe defects in CKD care could be eliminated and were a collective responsibility. Belonging fostered the creation of learning communities that broke down silos and encouraged open communication and collaboration between PCPs and nephrologists. Building involved constructing a fractal management infrastructure with transparent reporting and shared accountability, which would enable success in innovation and transformation. The result is proactive and relational CKD care organized around the patient's needs in University Hospitals Systems of Excellence. Systems of excellence combine multiple domains of expertise to promote best practice guidelines and integrate care throughout the system. The authors further describe a preliminary pilot of the CKD System of Excellence in primary care.