{Reference Type}: Journal Article
{Title}: Glechomenes A-G, diterpenoids with anti-inflammatory activities from the aerial part of Glechoma longituba.
{Author}: Zhang Q;Lu M;Liu T;Zheng X;Chen T;Yang L;Ding L;Yang Y;Han Z;Gu L;Wang Z;
{Journal}: Fitoterapia
{Volume}: 176
{Issue}: 0
{Year}: 2024 Jul 23
{Factor}: 3.204
{DOI}: 10.1016/j.fitote.2024.106034
{Abstract}: Ten diterpenoids including six unreported abietane-type diterpenoids Glecholmenes A-F (1-6) and an undescribed labdane-type diterpenoid Glecholmene G (9), together with three known diterpenoids (7,8,10), were firstly isolated from the aerial part of G. longituba. Their structures were established mainly by nuclear magnetic resonance (NMR) and high-resolution electrospray ionization mass spectrometry (HR-ESI-MS) methods. Electronic circular dichroism (ECD) calculations and X-ray crystallographic analyses were used for the determination of their absolute configurations. The anti-inflammatory activity of all compounds was evaluated using the classical LPS-induced NO release model in RAW264.7 cells. Compound 2 displayed significant anti-inflammatory activities with IC50 values of 29.08 ± 1.40 μM (Aminoguanidine hydrochloride as the positive control, IC50 = 21.84 ± 0.48 μM).