{Reference Type}: Journal Article
{Title}: Impairment of olfactory identification ability in ultra-high risk for psychosis and drug-naïve first episode psychosis.
{Author}: Ouyang L;Ma X;Yuan L;Fan L;Liao A;Li D;Yang Z;Zhang Z;Liu W;Chen X;Li Z;He Y;
{Journal}: Prog Neuropsychopharmacol Biol Psychiatry
{Volume}: 133
{Issue}: 0
{Year}: 2024 Jul 13
{Factor}: 5.201
{DOI}: 10.1016/j.pnpbp.2024.111035
{Abstract}: <B>OBJECTIVE: </B>Patients with psychotic diseases have been reported to exhibit abnormalities in their olfactory discrimination. These alterations have also been identified in people at high genetic or clinical risk for psychosis, suggesting olfactory discrimination dysfunction may be a potential risk factor for developing psychosis. Thus, the purpose of our study is to explore the difference in olfactory discrimination ability in the prosal stage and early stage of psychosis and to explore the potential risk factor of developed psychosis.<BR><B>METHODS: </B>We compared olfactory identification and cognitive function in 89 ultra-high-risk (UHR) individuals, 103 individuals with Drug-naïve first-episode schizophrenia (FES), 81 genetic high-risk (GHR) individuals, and 97 healthy controls (HC). Additionally, we compared olfactory identification and cognitive function between two groups; UHR individuals who later transitioned to psychosis (UHR-T; n = 33) and those who did not transition (UHR-NT; n = 42)). Furthermore, we analyzed the correlations between olfactory discrimination ability and cognitive function and symptoms and compared the olfactory function between men and women.<BR><B>RESULTS: </B>Patients with first-episode schizophrenia (FES) and those at ultra-high risk (UHR) for psychosis exhibited more significant deficits in olfactory identification than healthy controls (HC), while no differences in olfactory identification dysfunction were observed between the genetic high risk (GHR) and HC groups. Notably, individuals in the UHR group who later developed psyhchosis displayed a steeper marked decline in their baseline olfactory identification ability than that of those in the UHR group who did not develop psychosis. Cognitive dysfunction is widely observed in both the FES and UHR groups, with a distinct correlation identified between olfactory discrimination function and cognitive performance. Finally, overall, women exhibit significantly superior olfactory function than men.<BR><B>CONCLUSIONS: </B>In conclusion, these findings suggest that impairment of olfactory identification exists in the early stage of psychosis. Olfactory identification dysfunction may therefore be a potential marker of predicting the transition to schizophrenia.