{Reference Type}: Journal Article
{Title}: Phentolamine and B vitamins for feeding intolerance in late preterm infants: a randomised trial.
{Author}: Lv YY;Gao N;He X;Fu J;Shen Y;Li MY;Zhang Q;Li HY;
{Journal}: Asia Pac J Clin Nutr
{Volume}: 33
{Issue}: 2
{Year}: 2024 Jun
{Factor}: 1.322
{DOI}: 10.6133/apjcn.202406_33(2).0006
{Abstract}: <B>OBJECTIVE: </B>Feeding intolerance (FI) is a common problem in late preterm infants (34 weeks ≤ gestational age < 37 weeks). This study aimed to evaluate the efficacy and safety of phentolamine combined with B vitamins in treating FI in late preterm infants and to explore its effects on gastrointestinal symptoms, inflammation and complications.<BR><B>METHODS: </B>We randomly assigned 118 late preterm infants with FI to a treatment group (n = 56) or a control group (n = 62). The treatment group received intravenous phentolamine and intramuscular B vitamins, whereas the control group received basic treatment only. We measured the time of disappearance of gastrointestinal symptoms, the time of basal at-tainment, the time of hospitalisation, the incidence of complications, the concentrations of inflammatory markers and the overall effective rate of treatment.<BR><B>RESULTS: </B>The treatment group had a shorter duration of gastrointestinal symptoms than did the control group (p < 0.01). The treatment group also had lower concentrations of inflammatory markers and a higher overall effective rate than did the control group (p < 0.05). There was no difference between the two groups in the time of hospitalisation, basal attainment, weight re-covery and the incidence of complications (p > 0.05).<BR><B>CONCLUSIONS: </B>Phentolamine and B vitamins can reduce gastrointestinal symptoms and inflammation in late preterm infants with FI but do not affect the occurrence of complications.