{Reference Type}: Journal Article
{Title}: Rose geranium in sesame oil nasal spray to improve nasal vestibulitis symptoms: a randomized controlled trial.
{Author}: Cathcart-Rake EJ;Steinert K;Smith D;Lewis-Peters S;Giridhar K;Novotny P;Dauer D;O'Connor A;Thomé S;Erickson MK;Friday BB;Loprinzi CL;
{Journal}: Support Care Cancer
{Volume}: 32
{Issue}: 6
{Year}: 2024 May 24
{Factor}: 3.359
{DOI}: 10.1007/s00520-024-08580-6
{Abstract}: OBJECTIVE: The purpose of this phase III randomized double-blinded controlled trial was to investigate the efficacy of a rose geranium in sesame oil (RG) nasal spray compared with an isotonic saline (IS) nasal spray for alleviating nasal vestibulitis symptoms among patients undergoing chemotherapy.
METHODS: Patients undergoing active chemotherapy who reported associated nasal symptoms were randomized 1:1 to receive RG or IS, administered twice daily for 2 weeks. Consenting participants completed nasal symptom questionnaires at baseline and then weekly while on treatment. The proportion of patients experiencing improvements in their nasal symptoms 2 weeks after initiating the nasal spray, using a six-point global impression of change score, was estimated within and between each randomized arm, and compared between arms, using Fisher's exact test. The estimated odds ratio was determined (95% confidence interval).
RESULTS: One hundred and six patients consented to this study; 43 participants in the RG arm and 41 in the IS arm were evaluable for the primary endpoint. Participants had a mean age of 57.8 years (SD 13.9). Demographic characteristics and baseline nasal symptoms were similar between arms. Of the evaluable participants who received RG, 67.4% reported improved nasal symptoms, compared with 36.6% of the participants who received IS (P = 0.009). Adverse events were sparse and did not differ between arms.
CONCLUSIONS: Rose geranium in sesame oil significantly improves nasal vestibulitis symptoms among patients undergoing chemotherapy.
BACKGROUND: NCT04620369.