{Reference Type}: Journal Article
{Title}: Association between speckle tracking echocardiography and pressure-volume loops during cardiogenic shock development.
{Author}: Frederiksen PH;Linde L;Gregers E;Udesen NLJ;Helgestad OK;Banke A;Dahl JS;Povlsen AL;Jensen LO;Larsen JP;Lassen J;Schmidt H;Ravn HB;Moller JE;
{Journal}: Open Heart
{Volume}: 11
{Issue}: 1
{Year}: 2024 May 23
暂无{DOI}: 10.1136/openhrt-2023-002512
{Abstract}: <B>BACKGROUND: </B>The relationship between speckle tracking assessed global longitudinal strain (GLS) and Doppler-based echocardiography with basic physiological markers of cardiac function derived from pressure-volume loops is poorly elucidated.<BR><B>OBJECTIVE: </B>We aimed to describe the association between LS and Doppler-based echocardiography and direct measurements of central haemodynamic parameters from conductance catheter-based pressure-volume loops in an animal model with increasing left ventricular (LV) dysfunction.<BR><B>METHODS: </B>12 Danish landrace female pigs (75-80 kg) were used. All instrumentations were performed percutaneously, including the conductance catheter in the LV. Progressive LV dysfunction was induced by embolisation through the left main coronary artery with microspheres every 3 min until a >50% reduction in cardiac output (CO) or mixed venous saturation (SvO2), compared with baseline, or SvO2 <30%. Echocardiography was performed at baseline and 90 s after each injection.<BR><B>RESULTS: </B>With progressive LV dysfunction, mean CO decreased from 5.6±0.9 L/min to 2.1±0.9 L/min, and mean SvO2 deteriorated from 61.1±7.9% to 35.3±6.1%. Mean LS and LV outflow tract velocity time integral (LVOT VTI) declined from -13.8±3.0% to -6.1±2.0% and 16.9±2.6 cm to 7.8±1.8 cm, respectively. LS and LVOT VTI showed the strongest correlation to stroke work in unadjusted linear regression (r2=0.53 and r2=0.49, respectively). LS correlated significantly with stroke volume, end-systolic elastance, systolic blood pressure, ventriculo-arterial coupling and arterial elastance.<BR><B>CONCLUSIONS: </B>In an animal model of acute progressive LV dysfunction, echocardiographic and conductance catheter-based measurements changed significantly. LS and LVOT VTI displayed the earliest and the largest alterations with increased myocardial damage and both correlated strongest with stroke work.