{Reference Type}: Journal Article
{Title}: Decoding the Enigma: Translation Termination in Human Mitochondria.
{Author}: Krüger A;Kovalchuk D;Shiriaev D;Rorbach J;
{Journal}: Hum Mol Genet
{Volume}: 33
{Issue}: 0
{Year}: 2024 May 22
{Factor}: 5.121
{DOI}: 10.1093/hmg/ddae032
{Abstract}: Mitochondrial translation is a complex process responsible for the synthesis of essential proteins involved in oxidative phosphorylation, a fundamental pathway for cellular energy production. Central to this process is the termination phase, where dedicated factors play a pivotal role in ensuring accurate and timely protein production. This review provides a comprehensive overview of the current understanding of translation termination in human mitochondria, emphasizing structural features and molecular functions of two mitochondrial termination factors mtRF1 and mtRF1a.