{Reference Type}: Journal Article
{Title}: Characteristics and outcomes of COVID-19 patients admitted to hospital with and without respiratory symptoms.
{Author}: Citarella BW;Kartsonaki C;Ibáñez-Prada ED;Gonçalves BP;Baruch J;Escher M;Pritchard MG;Wei J;Philippy F;Dagens A;Hall M;Lee J;Kutsogiannis DJ;Wils EJ;Fernandes MA;Tirupakuzhi Vijayaraghavan BK;Panda PK;Martin-Loeches I;Ohshimo S;Fatoni AZ;Horby P;Dunning J;Rello J;Merson L;Rojek A;Vaillant M;Olliaro P;Reyes LF; ;
{Journal}: Heliyon
{Volume}: 10
{Issue}: 10
{Year}: 2024 May 30
{Factor}: 3.776
{DOI}: 10.1016/j.heliyon.2024.e29591
{Abstract}: <B>UNASSIGNED: </B>COVID-19 is primarily known as a respiratory illness; however, many patients present to hospital without respiratory symptoms. The association between non-respiratory presentations of COVID-19 and outcomes remains unclear. We investigated risk factors and clinical outcomes in patients with no respiratory symptoms (NRS) and respiratory symptoms (RS) at hospital admission.<BR><B>UNASSIGNED: </B>This study describes clinical features, physiological parameters, and outcomes of hospitalised COVID-19 patients, stratified by the presence or absence of respiratory symptoms at hospital admission. RS patients had one or more of: cough, shortness of breath, sore throat, runny nose or wheezing; while NRS patients did not.<BR><B>UNASSIGNED: </B>Of 178,640 patients in the study, 86.4 % presented with RS, while 13.6 % had NRS. NRS patients were older (median age: NRS: 74 vs RS: 65) and less likely to be admitted to the ICU (NRS: 36.7 % vs RS: 37.5 %). NRS patients had a higher crude in-hospital case-fatality ratio (NRS 41.1 % vs. RS 32.0 %), but a lower risk of death after adjusting for confounders (HR 0.88 [0.83-0.93]).<BR><B>UNASSIGNED: </B>Approximately one in seven COVID-19 patients presented at hospital admission without respiratory symptoms. These patients were older, had lower ICU admission rates, and had a lower risk of in-hospital mortality after adjusting for confounders.