{Reference Type}: Journal Article
{Title}: The utility of serum neutrophil gelatinase-associated lipocalin level on predicting autosomal dominant polycystic kidney disease progression.
{Author}: Uysal C;Koyuncu S;Ipekten F;Karakukcu C;Kocyigit I;
{Journal}: Ther Apher Dial
{Volume}: 0
{Issue}: 0
{Year}: 2024 May 21
{Factor}: 2.195
{DOI}: 10.1111/1744-9987.14163
{Abstract}: <B>BACKGROUND: </B>We focused on neutrophil gelatinase-associated lipocalin (NGAL) and autosomal dominant polycystic kidney disease (ADPKD) progression.<BR><B>METHODS: </B>ADPKD patients with an estimated glomerular filtration rate (eGFR) ≥ 30 mL/min/1.73 m2 were included. Serum NGAL level and NGAL to eGFR ratio (NGR), height-adjusted total kidney volume (hTKV) were assessed initially. Patients were followed-up for 5 years.<BR><B>RESULTS: </B>Sixty one patients were enrolled and initial eGFR was 73.6 (48.9-101.5) ml/min/1.73m2. EGFR declined by 3.7 mL/min/1.73m2 per year. Thirty four patients (55.7%) exhibited rapid progression. Rapid progression group had lower serum NGAL levels (p < 0.001) and higher hTKV (p < 0.001). Lower serum NGAL level was a risk factor for rapid progression (p < 0.001). NGR was not associated with rapid progression. Serum NGAL level was predictive in for rapid progression ROC analysis (cut-off <10.62 ng/mL).<BR><B>CONCLUSIONS: </B>Relatively lower serum NGAL levels can predict worse outcomes in ADPKD and can provide risk stratification in patients with ADPKD.