{Reference Type}: Journal Article
{Title}: RB1: governor of the cell cycle in health and disease-a primer for the practising pathologist.
{Author}: Cordier F;Creytens D;
{Journal}: J Clin Pathol
{Volume}: 77
{Issue}: 7
{Year}: 2024 Jun 19
{Factor}: 4.463
{DOI}: 10.1136/jcp-2024-209480
{Abstract}: RB1 stands as the pioneering discovery in tumour-suppressor genes, marking a pivotal breakthrough in comprehending cancer development. This overview delves into the role of RB1 in both health and disease, exploring its association with the tumourigenesis of various cancers and a distinct subset of soft-tissue neoplasms. Additionally, we discuss the application of immunohistochemistry and fluorescence in situ hybridisation to detect RB1 alterations.