{Reference Type}: Journal Article
{Title}: Clinical, paraclinical and outcome features of 166 patients with acute anti-GQ1b antibody syndrome.
{Author}: Coly M;Adams D;Attarian S;Bouhour F;Camdessanché JP;Carey G;Cauquil C;Chanson JB;Chrétien P;Créange A;Delmont E;Fargeot G;Frachet S;Gendre T;Kuntzer T;Labeyrie C;Maisonobe T;Michaud M;Moulin M;Nicolas G;Noury JB;Péréon Y;Puma A;Sole G;Taithe F;Tard C;Théaudin M;Timsit S;Venditti L;Echaniz-Laguna A;
{Journal}: J Neurol
{Volume}: 271
{Issue}: 8
{Year}: 2024 Aug 20
{Factor}: 6.682
{DOI}: 10.1007/s00415-024-12410-4
{Abstract}: <B>OBJECTIVE: </B>In this retrospective study, we aimed at defining the clinical, paraclinical and outcome features of acute neurological syndromes associated with anti-GQ1b antibodies.<BR><B>RESULTS: </B>We identified 166 patients with neurological symptoms appearing in less than 1 month and anti-GQ1b antibodies in serum between 2012 and 2022. Half were female (51%), mean age was 50 years (4-90), and the most frequent clinical features were areflexia (80% of patients), distal upper and lower limbs sensory symptoms (78%), ophthalmoplegia (68%), sensory ataxia (67%), limb muscle weakness (45%) and bulbar weakness (45%). Fifty-three patients (32%) presented with complete (21%) and incomplete (11%) Miller Fisher syndrome (MFS), thirty-six (22%) with Guillain-Barre syndrome (GBS), one (0.6%) with Bickerstaff encephalitis (BE), and seventy-three (44%) with mixed MFS, GBS & BE clinical features. Nerve conduction studies were normal in 46% of cases, showed demyelination in 28%, and axonal loss in 23%. Anti-GT1a antibodies were found in 56% of cases, increased cerebrospinal fluid protein content in 24%, and Campylobacter jejuni infection in 7%. Most patients (83%) were treated with intravenous immunoglobulins, and neurological recovery was complete in 69% of cases at 1 year follow-up. One patient died, and 15% of patients relapsed. Age > 70 years, initial Intensive Care Unit (ICU) admission, and absent anti-GQ1b IgG antibodies were predictors of incomplete recovery at 12 months. No predictors of relapse were identified.<BR><B>CONCLUSIONS: </B>This study from Western Europe shows acute anti-GQ1b antibody syndrome presents with a large clinical phenotype, a good outcome in 2/3 of cases, and frequent relapses.