{Reference Type}: Journal Article
{Title}: The roles of B cells in cardiovascular diseases.
{Author}: Ma J;Wang X;Jia Y;Tan F;Yuan X;Du J;
{Journal}: Mol Immunol
{Volume}: 171
{Issue}: 0
{Year}: 2024 Jul 18
{Factor}: 4.174
{DOI}: 10.1016/j.molimm.2024.05.002
{Abstract}: Damage to the heart can start the repair process and cause cardiac remodeling. B cells play an important role in this process. B cells are recruited to the injured place and activate cardiac remodeling through secreting antibodies and cytokines. Different types of B cells showed specific functions in the heart. Among all types of B cells, heart-associated B cells play a vital role in the heart by secreting TGFβ1. B cells participate in the activation of fibroblasts and promote cardiac fibrosis. Four subtypes of B cells in the heart revealed the relationship between the B cells' heterogeneity and cardiac remodeling. Many cardiovascular diseases like atherosclerosis, heart failure (HF), hypertension, myocardial infarction (MI), and dilated cardiomyopathy (DCM) are related to B cells. The primary mechanisms of these B cell-related activities will be discussed in this review, which may also suggest potential novel therapeutic targets.