{Reference Type}: Journal Article
{Title}: Association of triglyceride glucose index and triglyceride glucose-body mass index with sudden cardiac arrest in the general population.
{Author}: Zhang S;Liu W;Xu B;Wang S;Du Z;Cheng W;
{Journal}: Cardiovasc Diabetol
{Volume}: 23
{Issue}: 1
{Year}: 2024 May 18
{Factor}: 8.949
{DOI}: 10.1186/s12933-024-02275-2
{Abstract}: <B>BACKGROUND: </B>Insulin resistance (IR) significantly contributes to cardiovascular disease (CVD) development. Triglyceride glucose (TyG) index and triglyceride glucose-body mass index (TyG-BMI) are recognised as convenient proxies for IR. However, their relationship with sudden cardiac arrest (SCA) remains unclear.<BR><B>METHODS: </B>This prospective cohort analysis included 355,242 UK Biobank participants with available TyG index and TyG-BMI data and no history of CVD. Cox proportional risk models assessed the association between the TyG index, TyG-BMI and SCA risk. Additionally, Accelerated Failure Time (AFT) models were employed to investigate the timing of SCA onset. The impact of dynamic increases in TyG index and TyG-BMI levels on SCA risk was examined using restricted cubic spline.<BR><B>RESULTS: </B>Over a median follow-up period of 165.4 months (interquartile range 156.5-174 months), 1,622 cases of SCA were recorded. Multivariate Cox regression analysis revealed a 9% increase in SCA risk per standard deviation increase in TyG index (adjusted hazard ratio (aHR) = 1.09, 95% confidence interval (CI) 1.04-1.15) and an 14% increase per standard deviation increase in TyG-BMI (aHR 1.14, 95% CI 1.09-1.2). AFT models indicated earlier median times to SCA occurrence with increasing quintiles of TyG index and TyG-BMI compared to the lowest quintile (P for trend < 0.05). SCA risk was linearly (P = 0.54) and non-linearly (P = 0.007) correlated with gradual increases in TyG index and TyG-BMI levels, respectively. Sex-stratified analyses showed stronger associations in women.<BR><B>CONCLUSIONS: </B>Higher TyG index and TyG-BMI levels are associated with an increased SCA risk and earlier onset, particularly in women.