{Reference Type}: Journal Article
{Title}: Two new jatrophane diterpenoids from Euphorbia helioscopia with activity towards autophagic flux.
{Author}: Peng MY;Zhang X;Li QD;Feng EM;Chen L;Yang HC;Guo B;Di YT;Tang L;Luo RC;Yan Y;
{Journal}: J Asian Nat Prod Res
{Volume}: 26
{Issue}: 8
{Year}: 2024 Aug 16
{Factor}: 1.61
{DOI}: 10.1080/10286020.2024.2345181
{Abstract}: Nine jatrophane diterpenoids were isolated from the whole plant Euphorbia helioscopia, including two new ones, helioscopnins A (1) and B (2). Comprehensive spectroscopic data analysis and ECD calculations elucidated their structures, including absolute configurations. All compounds were evaluated for bioactivity towards autophagic flux by flow cytometry using HM mCherry-GFP-LC3 cells. Compounds 1, 3, 4, 5, 8, and 9 significantly increased autophagic flux.