{Reference Type}: Journal Article {Title}: A new superhero, the intraepithelial mast cell, joins the "Guardians of the Gut". {Author}: Zaini A;Harris NL; {Journal}: Immunity {Volume}: 57 {Issue}: 5 {Year}: 2024 May 14 {Factor}: 43.474 {DOI}: 10.1016/j.immuni.2024.04.020 {Abstract}: The intestinal epithelium interacts with immune cells to support tissue homeostasis and coordinate responses against pathogens. In this issue of Immunity, Yang et al. unveil a central role for mast cell-epithelial cell interactions in orchestrating protective type 2 immune responses following intestinal helminth infection.